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Takuya Watanabe Selected Research

(2- (4- (2- benzimidazol- 2ylthio)ethyl)piperazin- 1yl)- N- (2,4- bis(methylthio)- 6- methyl- 3- pyridyl)acetamide

11/2010A selective ACAT-1 inhibitor, K-604, stimulates collagen production in cultured smooth muscle cells and alters plaque phenotype in apolipoprotein E-knockout mice.
4/2007A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels.

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Takuya Watanabe Research Topics

Disease

44Atherosclerosis
06/2021 - 03/2002
27Neoplasms (Cancer)
12/2021 - 08/2002
21Atherosclerotic Plaque (Atheroma)
04/2021 - 01/2002
13Heart Failure
09/2022 - 07/2015
13Alzheimer Disease (Alzheimer's Disease)
12/2019 - 10/2005
11Coronary Artery Disease (Coronary Atherosclerosis)
04/2021 - 12/2005
11Carotid Artery Diseases
05/2019 - 09/2003
9Insulin Resistance
10/2021 - 03/2008
8Hypertension (High Blood Pressure)
10/2021 - 10/2005
8Inflammation (Inflammations)
01/2020 - 01/2016
7Glioma (Gliomas)
01/2020 - 04/2009
7Neoplasm Metastasis (Metastasis)
11/2019 - 06/2003
7Cardiovascular Diseases (Cardiovascular Disease)
01/2018 - 12/2008
6Myocarditis (Carditis)
02/2022 - 09/2017
6Brain Ischemia (Cerebral Ischemia)
03/2018 - 06/2006
6Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy)
06/2009 - 01/2004
6Intervertebral Disc Degeneration
06/2008 - 11/2005
5Type 2 Diabetes Mellitus (MODY)
10/2021 - 12/2008
5Thrombosis (Thrombus)
03/2020 - 05/2000
5Amyloid Plaque
12/2019 - 06/2006
5Stomach Neoplasms (Stomach Cancer)
01/2019 - 06/2003
5Dementia (Dementias)
03/2018 - 01/2004
5Glioblastoma (Glioblastoma Multiforme)
01/2015 - 02/2009
5Essential Hypertension
02/2007 - 03/2002
4Stroke (Strokes)
09/2022 - 11/2007
4Infections
01/2022 - 04/2005
4Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2022 - 07/2018
4Lung Neoplasms (Lung Cancer)
11/2021 - 01/2015
4Hyperplasia
04/2021 - 05/2000
4Synovial Sarcoma (Synovioma)
10/2012 - 12/2005
3Ischemia
06/2021 - 06/2006
3Anemia
04/2021 - 08/2018
3Hepatocellular Carcinoma (Hepatoma)
01/2020 - 01/2013
3Cerebral Infarction
02/2018 - 09/2009
3Obesity
01/2017 - 12/2008
3Body Weight (Weight, Body)
01/2015 - 07/2012
2Sleep Apnea Syndromes (Sleep Apnea)
09/2022 - 01/2017
2Pneumothorax
05/2022 - 01/2019
2Neutropenia
01/2022 - 01/2019
2Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
12/2021 - 01/2020
2Left Ventricular Dysfunction
12/2021 - 10/2021
2Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy)
12/2021 - 09/2019
2Cardiogenic Shock
11/2021 - 09/2017
2Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal)
10/2021 - 01/2017
2Colonic Neoplasms (Colon Cancer)
09/2021 - 01/2021

Drug/Important Bio-Agent (IBA)

21Peptides (Polypeptides)IBA
06/2021 - 03/2002
15Glucose (Dextrose)FDA LinkGeneric
10/2021 - 04/2005
15Apolipoproteins E (ApoE)IBA
04/2021 - 09/2010
12Proteins (Proteins, Gene)FDA Link
01/2020 - 11/2002
12oxidized low density lipoproteinIBA
01/2015 - 01/2002
11ApolipoproteinsIBA
06/2021 - 10/2008
11urotensin IIIBA
06/2009 - 07/2002
10Vasoconstrictor AgentsIBA
01/2020 - 10/2005
9Biomarkers (Surrogate Marker)IBA
06/2021 - 06/2009
8Biological ProductsIBA
05/2018 - 01/2006
5Insulin (Novolin)FDA Link
10/2021 - 09/2003
5Pharmaceutical PreparationsIBA
09/2021 - 06/2006
5CollagenIBA
02/2018 - 11/2010
5Amyloid beta-PeptidesIBA
01/2015 - 06/2006
5LipidsIBA
01/2015 - 08/2002
5Insulin-Like Growth Factor I (IGF-1)IBA
08/2010 - 09/2003
4Tyrosine (L-Tyrosine)FDA Link
01/2020 - 05/2009
4Paclitaxel (Taxol)FDA LinkGeneric
07/2018 - 06/2003
4Acetylcholine (Acetylcholine Chloride)FDA Link
03/2018 - 06/2006
4AntibodiesIBA
01/2018 - 04/2005
4CholesterolIBA
01/2018 - 04/2007
4Cholinergic Agents (Cholinergics)IBA
07/2013 - 01/2008
4DNA (Deoxyribonucleic Acid)IBA
03/2009 - 01/2002
4Serotonin (5 Hydroxytryptamine)IBA
11/2007 - 01/2002
3Cyclosporine (Ciclosporin)FDA LinkGeneric
02/2022 - 03/2011
3InterferonsIBA
04/2021 - 09/2006
3ErythropoietinFDA Link
01/2020 - 05/2000
3Phosphotransferases (Kinase)IBA
01/2020 - 01/2013
3Peptide Hydrolases (Proteases)FDA Link
10/2019 - 10/2003
3CoffeeFDA Link
07/2019 - 07/2006
3Yi-Gan SanIBA
01/2019 - 07/2013
3Cisplatin (Platino)FDA LinkGeneric
10/2018 - 04/2007
3Hormones (Hormone)IBA
05/2018 - 04/2004
3salicylhydroxamic acid (SHAM)IBA
03/2018 - 03/2011
3Angiotensin IIIBA
08/2016 - 07/2002
3Glucagon-Like Peptide 1 (GLP 1)IBA
04/2014 - 07/2012
3Prion ProteinsIBA
12/2012 - 10/2010
3Donepezil (Aricept)FDA LinkGeneric
08/2010 - 06/2006
3Messenger RNA (mRNA)IBA
02/2009 - 05/2000
3Lipoprotein(a)IBA
04/2005 - 01/2004
3Lipid PeroxidesIBA
04/2005 - 01/2004
3LDL CholesterolIBA
04/2005 - 01/2004
2SteroidsIBA
05/2022 - 09/2006
2Oxaliplatin (Eloxatin)FDA LinkGeneric
09/2021 - 10/2011

Therapy/Procedure

24Therapeutics
02/2022 - 06/2003
19Heart-Assist Devices
09/2022 - 06/2014
5Extracorporeal Membrane Oxygenation
09/2022 - 09/2017
5Transplantation
01/2022 - 11/2005
5Heart Transplantation (Grafting, Heart)
09/2019 - 06/2013
4Drug Therapy (Chemotherapy)
07/2018 - 10/2012
3Operative Surgical Procedures
05/2022 - 01/2021
3Chemoradiotherapy
12/2021 - 07/2013
3Radiotherapy
07/2020 - 10/2012
2Pleurodesis
05/2022 - 01/2019
2Segmental Mastectomy (Lumpectomy)
11/2021 - 07/2020